TrumpRx GLP-1 Prices 2026: What Ozempic and Wegovy Cost Under Trump's Drug Plan
A patient I heard from recently described standing at her pharmacy counter, prescription in hand, watching the cashier ring up $947 for one month of Ozempic. She handed it back. She couldn't afford it — and she walked out without the medication her doctor had prescribed. That story used to feel inevitable. Here's what they don't tell you: as of May 2026, it doesn't have to be anymore.
TrumpRx.gov — the federal drug purchasing portal launched February 5, 2026, and significantly expanded on May 18, 2026 — has changed the math for GLP-1 medications like Ozempic and Wegovy. The prices under Trump's Most-Favored-Nation executive order are not estimates or projections. They are live prices, available right now, for eligible patients who know where to look.
I've been tracking this since the portal launched. Let me break this down so you know exactly what you're looking at.
What Is TrumpRx.gov?
TrumpRx.gov is a federally backed direct-purchasing portal that gives Americans access to prescription medications at prices negotiated directly by the federal government. It bypasses the traditional pharmacy benefit manager (PBM) middlemen — the intermediaries whose rebate structures and spread pricing have contributed to the gap between what drugs actually cost to produce and what patients pay at the counter.
The program is built on Trump's Most-Favored-Nation (MFN) executive order, which caps the price the U.S. pays for certain drugs to match the lowest prices paid by comparable developed nations — countries like the United Kingdom, Germany, France, Canada, and Japan. For years, Americans have paid 2 to 5 times what people in those countries pay for the same medication, made by the same manufacturer, from the same factory. MFN pricing closes that gap.
As of the May 2026 expansion, 17 major pharmaceutical manufacturers have signed agreements covering 86% of the branded drug market. GLP-1 medications — including Ozempic (semaglutide), Wegovy (semaglutide), Mounjaro (tirzepatide), and Zepbound (tirzepatide) — are covered under these deals.
Current TrumpRx GLP-1 Prices (as of May 2026)
Here's what the numbers actually look like under MFN pricing:
| Medication | Retail Price | TrumpRx MFN Price | Monthly Savings | Annual Savings |
|---|---|---|---|---|
| Ozempic (semaglutide, 1mg) | ~$900/month | ~$285/month | ~$615 | ~$7,380 |
| Wegovy (semaglutide, 2.4mg) | ~$1,350/month | ~$349/month | ~$1,001 | ~$12,012 |
Those are real numbers. Ozempic at $285 a month is a 68% reduction from retail. Wegovy at $349 is a 74% reduction. Over one year on Wegovy, a patient accessing TrumpRx pricing instead of paying retail saves over $12,000.
I want to be clear about what these prices represent: they are the government-negotiated MFN prices that TrumpRx.gov is making available as of May 2026. They are not GoodRx coupon prices, manufacturer savings cards, or telehealth program pricing — those are separate programs with different eligibility rules and cost structures. Use our GLP-1 cost calculator to compare all your options side by side.
Who Can Access TrumpRx GLP-1 Prices?
The program is designed primarily for uninsured and underinsured Americans — patients who have been paying retail or near-retail prices for GLP-1 medications without meaningful coverage. If you have Medicare, Medicaid, or comprehensive employer insurance that already covers your GLP-1 at a low copay, TrumpRx may not stack on top of that coverage.
But if you've been paying out-of-pocket — or your insurance explicitly excludes GLP-1 drugs for weight loss (which remains common in many employer plans) — TrumpRx pricing is likely accessible to you. Eligibility details are on TrumpRx.gov directly, and I'd encourage every patient in that situation to check before assuming they don't qualify.
Here's what they don't tell you about the eligibility rules: they're designed to be broad. The goal of the program is to expand access, not to create new bureaucratic barriers. The application process on TrumpRx.gov is designed to be fast — most patients can confirm eligibility in minutes.
How TrumpRx Compares to Other Savings Programs
Let me put these numbers in context against the other main savings options GLP-1 patients use:
- Manufacturer savings cards (Novo Nordisk, Eli Lilly): These can bring costs to $0-$25/month for commercially insured patients — but they can't be used with Medicare or Medicaid, and many patients with employer insurance that excludes GLP-1s don't qualify.
- GoodRx: Typically brings Ozempic to $800-$850 at major pharmacies. Significant savings over retail, but still roughly three times TrumpRx pricing.
- Telehealth compounded GLP-1 programs: Starting prices often $125-$299/month for compounded semaglutide or tirzepatide — a different regulatory category than brand-name drugs, but price-competitive with TrumpRx in some cases.
- TrumpRx MFN pricing: $285-$349/month for brand-name Ozempic and Wegovy, from a licensed pharmacy, with standard FDA oversight.
For uninsured patients who've been paying retail, TrumpRx represents the most significant price reduction available for brand-name GLP-1 medications. It doesn't require a telehealth subscription, doesn't involve compounded formulations, and provides the same FDA-approved medication at a fraction of retail cost.
What About Mounjaro and Zepbound?
Mounjaro (tirzepatide for diabetes) and Zepbound (tirzepatide for weight management) are included in the MFN framework under the May 2026 expansion. Official per-unit pricing for these drugs through TrumpRx continues to be finalized as manufacturers complete their agreements. Check TrumpRx.gov directly for the most current pricing — the portal updates as agreements are confirmed.
How to Use TrumpRx to Get These Prices
I've been through enough insurance battles to know that a good price means nothing if you can't actually access it. Here's the practical path:
- Visit TrumpRx.gov and search for your specific GLP-1 medication by name.
- Confirm your eligibility — the portal walks you through this in a brief questionnaire.
- Receive a voucher or authorization code to present at a participating pharmacy.
- Fill your prescription at the MFN negotiated price.
The portal lists participating pharmacies by zip code. Major chains are included, as are many independent pharmacies. If your usual pharmacy isn't participating yet, check the full list — the network has expanded significantly since the February launch.
Use the Calculator to Model Your Personal Savings
The numbers above are averages. Your specific situation — which drug, which dose, your insurance status, your state — affects what you'll actually pay. Our free GLP-1 cost calculator lets you compare TrumpRx pricing against your current cost and other available programs in about 60 seconds. Run your numbers before your next pharmacy visit.
Also considering a GLP-1 telehealth program?
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Bottom Line
The pharmacy receipt that sent a patient home without her medication doesn't have to be the ending anymore. TrumpRx.gov prices — Ozempic at ~$285, Wegovy at ~$349, as of May 2026 — represent the most significant reduction in brand-name GLP-1 pricing this country has ever seen for patients paying out-of-pocket.
Check your eligibility. Run your numbers. And if TrumpRx doesn't apply to your situation, our calculator will show you the next best option — whether that's a manufacturer savings card, a telehealth program, or something else entirely. You have more options than that pharmacy counter made it seem.